Solid-state, maintenance-free, dissolved carbon dioxide sensor
With a goal of giving bioproduction scientists and engineers greater control to measure, monitor, and automate fermentation processes, Hamilton Process Analytics announced a new optical dissolved carbon dioxide (DCO₂) sensor for use in R&D, pilot, and production bioreactor applications.
Dubbed “CO₂NTROL”, the DCO₂ probe leverages a solid-state, optical measurement principle and requires no maintenance outside of simple calibration. Unlike other DCO₂ measurement technologies such as off-line blood-gas analyzers and maintenance-heavy electrochemical (Severinghaus) electrodes, CO₂NTROL sensors offer the ideal combination of real-time, in-situ data that is accurate, precise, and not labor-intensive.
With a measurement range of 5 - 1,000 mbar (0.5 to 100 %-Vol or 7.5 - 1,500 mg/L), CO₂NTROL also comes with standard Hamilton Arc technology, boasting an integrated micro-transmitter that stores calibration and quality data and makes calibration possible in a controlled metrology lab. The robust sensor is also ready for CIP, SIP, and autoclave.
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Hamilton offers two detailed white papers on dissolved carbon dioxide’s important role in bioprocessing:
- “Should Dissolved CO₂ Be a Critical Process Parameter?” explores why the FDA’s Process Analytical Technology framework categorizes DCO₂ as a CPP. For instance, by influencing other culture parameters such as extracellular and intracellular pH or key performance indicators such as viable cell density, DCO₂ has a direct impact on product titer and its critical quality attributes.
- “Are Current Dissolved CO₂ Measurement Technologies Good Enough?” reviews existing strategies and equipment currently used to measure DCO₂, including indirect measurement (soft sensors), reference and blood-gas analyzers (BGAs), off-gas analyzers, and electrochemical (Severinghaus) sensors.
Hamilton Process Analytics’ portfolio now includes six key critical process parameter measurements for the bioreactor:
- pH and ORP, or redox
- dissolved oxygen
- dissolved carbon dioxide
- viable cell density
- total cell density.